Strengthening America's Best Idea: An Independent Review of the National Park Service's Natural Resource Stewardship and Science Directorate

NRSS requested that an independent panel of the National Academy conduct a review of its effectiveness in five core functions, its relationships with key internal stakeholders, and its performance measurement system. Among other things, the National Park Service's Natural Resource Stewardship and Science Directorate (NRSS) is responsible for providing usable natural and social science information throughout the National Park Service (NPS). NRSS leadership requested this review of the directorate's performance on five core functions, its relationships with key internal NPS stakeholders, and its performance measurement system.Main FindingsThe panel determined that NRSS is a highly regarded organization that provides independent, credible scientific expertise and technical information. The panel also found that NRSS and NPS have additional opportunities to advance natural resource stewardship throughout the Service. If implemented, the panel's eight major recommendations will: (1) help the Service respond to the parks' environmental challenges while raising public awareness about the condition of these special places; (2) strengthen NRSS as an organization; (3) promote scientifically based decision-making at the national, regional, and park levels; and (4) improve the existing performance measurement system

Carrying Capacity in the National Parks

4 pages

Carrying Capacity in the National Parks

4 pages

Radio Observations of Supernova Remnant G1.9+0.3

We present 1–10 GHz radio continuum flux density, spectral index, polarization, and rotation measure (RM) images of the youngest known Galactic supernova remnant (SNR) G1.9+0.3, using observations from the Australia Telescope Compact Array. We have conducted an expansion study spanning eight epochs between 1984 and 2017, yielding results consistent with previous expansion studies of G1.9+0.3. We find a mean radio continuum expansion rate of (0.78 ± 0.09) per cent yr$^{−1}$ (or ∼8900 km s$^{−1}$ at an assumed distance of 8.5 kpc), although the expansion rate varies across the SNR perimetre. In the case of the most recent epoch between 2016 and 2017, we observe faster-than-expected expansion of the northern region. We find a global spectral index for G1.9+0.3 of −0.81 ± 0.02 (76 MHz–10 GHz). Towards the northern region, however, the radio spectrum is observed to steepen significantly (∼−1). Towards the two so-called (east and west) ‘ears’ of G1.9+0.3, we find very different RM values of 400–600 and 100–200 rad m$^2$, respectively. The fractional polarization of the radio continuum emission reaches (19 ± 2) per cent, consistent with other, slightly older, SNRs such as Cas A

Radio observations of supernova remnant G1.9+0.3

We present 1–10 GHz radio continuum flux density, spectral index, polarization, and rotation measure (RM) images of the youngest known Galactic supernova remnant (SNR) G1.9+0.3, using observations from the Australia Telescope Compact Array. We have conducted an expansion study spanning eight epochs between 1984 and 2017, yielding results consistent with previous expansion studies of G1.9+0.3. We find a mean radio continuum expansion rate of (0.78 ± 0.09) per cent yr−1 (or ∼8900 km s−1 at an assumed distance of 8.5 kpc), although the expansion rate varies across the SNR perimetre. In the case of the most recent epoch between 2016 and 2017, we observe faster-than-expected expansion of the northern region. We find a global spectral index for G1.9+0.3 of −0.81 ± 0.02 (76 MHz–10 GHz). Towards the northern region, however, the radio spectrum is observed to steepen significantly (∼−1). Towards the two so-called (east and west) ‘ears’ of G1.9+0.3, we find very different RM values of 400–600 and 100–200 rad m2, respectively. The fractional polarization of the radio continuum emission reaches (19 ± 2) per cent, consistent with other, slightly older, SNRs such as Cas A

Combination small molecule PPT1 mimetic and CNS-directed gene therapy as a treatment for infantile neuronal ceroid lipofuscinosis

Infantile neuronal ceroid lipofuscinosis (INCL) is a profoundly neurodegenerative disease of children caused by a deficiency in the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1). There is currently no effective therapy for this invariably fatal disease. To date, preclinical experiments using single treatments have resulted in incremental clinical improvements. Therefore, we determined the efficacy of CNS-directed AAV2/5-mediated gene therapy alone and in combination with the systemic delivery of the lysosomotropic PPT1 mimetic phosphocysteamine. Since CNS-directed gene therapy provides relatively high levels of PPT1 activity to specific regions of the brain, we hypothesized that phosphocysteamine would complement that activity in regions expressing sub therapeutic levels of the enzyme. Results indicate that CNS-directed gene therapy alone provided the greatest improvements in biochemical and histological measures as well as motor function and life span. Phosphocysteamine alone resulted in only minor improvements in motor function and no increase in lifespan. Interestingly, phosphocysteamine did not increase the biochemical and histological response when combined with AAV2/5-mediated gene therapy, but it did result in an additional improvement in motor function. These data suggest that a CNS-directed gene therapy approach provides significant clinical benefit, and the addition of the small molecule PPT1 mimetic can further increase that response